Reelin and brain development

Fadel Tissir; André M. Goffinet

doi:10.1038/nrn1113

Reelin and brain development

Fadel Tissir, André M. Goffinet^*

^*Corresponding author for this work

Université catholique de Louvain

Research output: Contribution to journal › Article › peer-review

657 Citations (Scopus)

Abstract

Over the last 50 years, the reeler mutant mouse has become an important model for studying normal and abnormal development in the cerebral cortex and other regions of the brain. However, we are only just beginning to understand the actions of reelin — the protein that is affected by the reeler mutation — at the molecular and cellular level. This review discusses the most recent advances in this research field, and considers the merits of the various models that have been put forward to explain how reelin works.

Original language	English
Pages (from-to)	496-505
Number of pages	10
Journal	Nature Reviews Neuroscience
Volume	4
Issue number	6
DOIs	https://doi.org/10.1038/nrn1113
Publication status	Published - Jun 2003
Externally published	Yes

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10.1038/nrn1113

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abstract = "Over the last 50 years, the reeler mutant mouse has become an important model for studying normal and abnormal development in the cerebral cortex and other regions of the brain. However, we are only just beginning to understand the actions of reelin — the protein that is affected by the reeler mutation — at the molecular and cellular level. This review discusses the most recent advances in this research field, and considers the merits of the various models that have been put forward to explain how reelin works.",

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Reelin and brain development

Abstract

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