Reelin receptors in developing laminated brain structures of mouse and human

Carlos G. Perez-Garcia*, F. Tissir, A. M. Goffinet, G. Meyer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Reelin is an extracellular matrix protein secreted by a variety of cell types throughout the developing brain. The target cells for reelin express the cytoplasmic adapter protein Dab1, which binds to the reelin receptors VLDLR and ApoER2. In the present work, we have studied the localization of both receptors in developing mouse and human cortex, olfactory bulb and cerebellum. In mouse, some Cajal-Retzius cells express reelin and VLDLR; in humans, all the components of the signalling pathway (Reelin, Dab1, VLDLR and ApoER2) are present in subsets of Cajal-Retzius cells. In the mouse cortical plate, VLDLR and ApoER2 are present from E15 to postnatal stages; in human cortical plate they are most prominent at ≈20 gestational weeks. In mice, cerebellar Purkinje cells only express VLDLR whereas in humans they express both VLDLR and ApoER2. Mitral cells of the mouse olfactory bulb are ApoER2-positive and VLDLR-negative. In sum, the receptor expression patterns are similar in the human and mouse cortical plate but differ in Cajal-Retzius and Purkinje cells, which in humans express additional components of the reelin-Dab1 pathway.

Original languageEnglish
Pages (from-to)2827-2832
Number of pages6
JournalEuropean Journal of Neuroscience
Volume20
Issue number10
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

Keywords

  • ApoER2
  • Cajal-Retzius cells
  • Reelin-Dab1 pathway
  • VLDLR

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