Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

A. Dyas; R. Wise; J. Pijck; Th Hallynck; J. Acar; D. Adam; R. Cadorniga; M. Wenk; H. H. Soep

doi:10.1093/jac/12.4.371

Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

A. Dyas, R. Wise^*, J. Pijck, Th Hallynck, J. Acar, D. Adam, R. Cadorniga, M. Wenk, H. H. Soep

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied.In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.

Original language	English
Pages (from-to)	371-376
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	12
Issue number	4
DOIs	https://doi.org/10.1093/jac/12.4.371
Publication status	Published - Oct 1983
Externally published	Yes

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abstract = "The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied.In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.",

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AU - Dyas, A.

AU - Wise, R.

AU - Pijck, J.

AU - Hallynck, Th

AU - Acar, J.

AU - Adam, D.

AU - Cadorniga, R.

AU - Wenk, M.

AU - Soep, H. H.

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AB - The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied.In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.

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ER -

Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

Abstract

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