Abstract
Rapid and real-time detection of l-cysteine (l-Cys) is important for early diagnostics of several diseases and biological disorders. We report here a stable and highly sensitive electrochemical sensor for the detection of l-Cys based on a Pd@Ti3C2Tx (MXene)-modified glassy carbon electrode (GCE). The Pd@Ti3C2Tx nanocomposite was prepared by in situ reduction of Pd(ii) salt on the surface of delaminated (DL) Ti3C2Tx nanosheets to form pseudo-spherical palladium nanoparticles (PdNPs) with 2-6 nm size distributions. The MXene acts as the conductive matrix and a reducing agent at the electrode surface, while PdNPs are there to improve the stability of Ti3C2Tx and to enhance the electrocatalytic activity towards l-Cys detection. The Pd@Ti3C2Tx/GCE sensor exhibited a detection limit of 0.14 μM and a linear electro-oxidative response to l-Cys within the concentration range from 0.5 to 10 μM. The sensor also demonstrated excellent selectivity over common interfering ions such as ascorbic acid, uric acid, dopamine and glucose.
Original language | English |
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Pages (from-to) | 3851-3856 |
Number of pages | 6 |
Journal | Analytical Methods |
Volume | 11 |
Issue number | 30 |
DOIs | |
Publication status | Published - 14 Aug 2019 |