TY - JOUR
T1 - Shaping the nervous system
T2 - Role of the core planar cell polarity genes
AU - Tissir, Fadel
AU - Goffinet, André M.
PY - 2013/8
Y1 - 2013/8
N2 - Planar cell polarity (PCP) is complementary to the intrinsic polarization of single cells and refers to the global coordination of cell behaviour in the plane of a tissue and, by extension, to the signalling pathways that control it. PCP is most evident in cell sheets, and research into PCP was for years confined to studies in Drosophila melanogaster. However, PCP has more recently emerged as an important phenomenon in vertebrates, in which it regulates various developmental processes and is associated with multiple disorders. In particular, core PCP genes are crucial for the development and function of the nervous system. They are involved in neural tube closure, ependymal polarity, neuronal migration, dendritic growth and axon guidance.
AB - Planar cell polarity (PCP) is complementary to the intrinsic polarization of single cells and refers to the global coordination of cell behaviour in the plane of a tissue and, by extension, to the signalling pathways that control it. PCP is most evident in cell sheets, and research into PCP was for years confined to studies in Drosophila melanogaster. However, PCP has more recently emerged as an important phenomenon in vertebrates, in which it regulates various developmental processes and is associated with multiple disorders. In particular, core PCP genes are crucial for the development and function of the nervous system. They are involved in neural tube closure, ependymal polarity, neuronal migration, dendritic growth and axon guidance.
UR - http://www.scopus.com/inward/record.url?scp=84880769695&partnerID=8YFLogxK
U2 - 10.1038/nrn3525
DO - 10.1038/nrn3525
M3 - Review article
C2 - 23839596
AN - SCOPUS:84880769695
SN - 1471-003X
VL - 14
SP - 525
EP - 535
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 8
ER -