Signaling molecules derived from the cholesterol biosynthetic pathway: Mechanisms of action and possible roles in human disease

Peter A. Edwards*, Johan Ericsson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)

Abstract

The association of high plasma cholesterol levels with the development of atherosclerosis is well known. The metabolic pathways that are regulated by cholesterol and the mechanisms involved are less well understood. Recent studies have identified not only cholesterol, but also oxysterols and isoprenoids, derived from the cholesterol biosynthetic pathway, as new signaling molecules. The transcriptional and post-transcriptional regulation of specific genes and metabolic pathways by these newly discovered signaling molecules may be important in the development of human disease and forms the topic of this review.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalCurrent Opinion in Lipidology
Volume9
Issue number5
DOIs
Publication statusPublished - 1998
Externally publishedYes

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