TY - JOUR
T1 - Signaling molecules derived from the cholesterol biosynthetic pathway
T2 - Mechanisms of action and possible roles in human disease
AU - Edwards, Peter A.
AU - Ericsson, Johan
PY - 1998
Y1 - 1998
N2 - The association of high plasma cholesterol levels with the development of atherosclerosis is well known. The metabolic pathways that are regulated by cholesterol and the mechanisms involved are less well understood. Recent studies have identified not only cholesterol, but also oxysterols and isoprenoids, derived from the cholesterol biosynthetic pathway, as new signaling molecules. The transcriptional and post-transcriptional regulation of specific genes and metabolic pathways by these newly discovered signaling molecules may be important in the development of human disease and forms the topic of this review.
AB - The association of high plasma cholesterol levels with the development of atherosclerosis is well known. The metabolic pathways that are regulated by cholesterol and the mechanisms involved are less well understood. Recent studies have identified not only cholesterol, but also oxysterols and isoprenoids, derived from the cholesterol biosynthetic pathway, as new signaling molecules. The transcriptional and post-transcriptional regulation of specific genes and metabolic pathways by these newly discovered signaling molecules may be important in the development of human disease and forms the topic of this review.
UR - http://www.scopus.com/inward/record.url?scp=0031788436&partnerID=8YFLogxK
U2 - 10.1097/00041433-199810000-00007
DO - 10.1097/00041433-199810000-00007
M3 - Review article
C2 - 9812197
AN - SCOPUS:0031788436
SN - 0957-9672
VL - 9
SP - 433
EP - 440
JO - Current Opinion in Lipidology
JF - Current Opinion in Lipidology
IS - 5
ER -