Sulfamic acid promoted one-pot multicomponent reaction: A facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

Trimurti L. Lambat; Ahmed A. Abdala; Sami Mahmood; Pankaj V. Ledade; Ratiram G. Chaudhary; Subhash Banerjee

doi:10.1039/c9ra08478a

Sulfamic acid promoted one-pot multicomponent reaction: A facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

Trimurti L. Lambat^*, Ahmed A. Abdala, Sami Mahmood, Pankaj V. Ledade, Ratiram G. Chaudhary, Subhash Banerjee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature.

Original language	English
Pages (from-to)	39735-39742
Number of pages	8
Journal	RSC Advances
Volume	9
Issue number	68
DOIs	https://doi.org/10.1039/c9ra08478a
Publication status	Published - 2019
Externally published	Yes

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abstract = "We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature.",

author = "Lambat, {Trimurti L.} and Abdala, {Ahmed A.} and Sami Mahmood and Ledade, {Pankaj V.} and Chaudhary, {Ratiram G.} and Subhash Banerjee",

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AU - Abdala, Ahmed A.

AU - Mahmood, Sami

AU - Ledade, Pankaj V.

AU - Chaudhary, Ratiram G.

AU - Banerjee, Subhash

PY - 2019

Y1 - 2019

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AB - We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature.

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U2 - 10.1039/c9ra08478a

DO - 10.1039/c9ra08478a

M3 - Article

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SN - 2046-2069

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JO - RSC Advances

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Sulfamic acid promoted one-pot multicomponent reaction: A facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

Abstract

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