SuPAR, an emerging biomarker in kidney and inflammatory diseases

Lamiaa Hamie; Georges Daoud; Georges Nemer; Tarek Nammour; Alissar El Chediak; Imad W. Uthman; Abdul Ghani Kibbi; Assaad Eid; Mazen Kurban

doi:10.1136/postgradmedj-2018-135839

SuPAR, an emerging biomarker in kidney and inflammatory diseases

Lamiaa Hamie, Georges Daoud, Georges Nemer, Tarek Nammour, Alissar El Chediak, Imad W. Uthman, Abdul Ghani Kibbi, Assaad Eid, Mazen Kurban^*

^*Corresponding author for this work

American University of Beirut

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

Soluble urokinase plasminogen activator receptor (suPAR) is a circulating form of a physiological and pathophysiological important cell surface receptor, implicated in inflammation. Recent studies showed that suPAR is a promising biomarker, useful for diagnosis, assessment and prognosis of several diseases. This review summarises the majority of preliminary studies and analyses the significance and the clinical application of suPAR in various clinical conditions. SuPAR seems to have a significant value in the diagnosis as well as prognosis of many diseases; nonetheless, it merits large-scale studies to set cut-off values that help physicians in following up their patients and accordingly tailor their treatment plans.

Original language	English
Pages (from-to)	517-524
Number of pages	8
Journal	Postgraduate Medical Journal
Volume	94
Issue number	1115
DOIs	https://doi.org/10.1136/postgradmedj-2018-135839
Publication status	Published - 1 Sept 2018
Externally published	Yes

Keywords

biomarker
diagnosis
inflammation
prognosis
screen
soluble urokinase plasminogen activator receptor

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10.1136/postgradmedj-2018-135839

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title = "SuPAR, an emerging biomarker in kidney and inflammatory diseases",

abstract = "Soluble urokinase plasminogen activator receptor (suPAR) is a circulating form of a physiological and pathophysiological important cell surface receptor, implicated in inflammation. Recent studies showed that suPAR is a promising biomarker, useful for diagnosis, assessment and prognosis of several diseases. This review summarises the majority of preliminary studies and analyses the significance and the clinical application of suPAR in various clinical conditions. SuPAR seems to have a significant value in the diagnosis as well as prognosis of many diseases; nonetheless, it merits large-scale studies to set cut-off values that help physicians in following up their patients and accordingly tailor their treatment plans.",

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AU - Hamie, Lamiaa

AU - Daoud, Georges

AU - Nemer, Georges

AU - Nammour, Tarek

AU - El Chediak, Alissar

AU - Uthman, Imad W.

AU - Kibbi, Abdul Ghani

AU - Eid, Assaad

AU - Kurban, Mazen

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Soluble urokinase plasminogen activator receptor (suPAR) is a circulating form of a physiological and pathophysiological important cell surface receptor, implicated in inflammation. Recent studies showed that suPAR is a promising biomarker, useful for diagnosis, assessment and prognosis of several diseases. This review summarises the majority of preliminary studies and analyses the significance and the clinical application of suPAR in various clinical conditions. SuPAR seems to have a significant value in the diagnosis as well as prognosis of many diseases; nonetheless, it merits large-scale studies to set cut-off values that help physicians in following up their patients and accordingly tailor their treatment plans.

AB - Soluble urokinase plasminogen activator receptor (suPAR) is a circulating form of a physiological and pathophysiological important cell surface receptor, implicated in inflammation. Recent studies showed that suPAR is a promising biomarker, useful for diagnosis, assessment and prognosis of several diseases. This review summarises the majority of preliminary studies and analyses the significance and the clinical application of suPAR in various clinical conditions. SuPAR seems to have a significant value in the diagnosis as well as prognosis of many diseases; nonetheless, it merits large-scale studies to set cut-off values that help physicians in following up their patients and accordingly tailor their treatment plans.

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KW - diagnosis

KW - inflammation

KW - prognosis

KW - screen

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JO - Postgraduate Medical Journal

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ER -

SuPAR, an emerging biomarker in kidney and inflammatory diseases

Abstract

Keywords

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