The acid test: The discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

Antony Galione; A. Mark Evans; Jianjie Ma; John Parrington; Abdelilah Arredouani; Xiaotong Cheng; Michael X. Zhu

doi:10.1007/s00424-009-0682-y

The acid test: The discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca²⁺ release channels

Antony Galione^*, A. Mark Evans, Jianjie Ma, John Parrington, Abdelilah Arredouani, Xiaotong Cheng, Michael X. Zhu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.

Original language	English
Pages (from-to)	869-876
Number of pages	8
Journal	Pflugers Archiv European Journal of Physiology
Volume	458
Issue number	5
DOIs	https://doi.org/10.1007/s00424-009-0682-y
Publication status	Published - Sept 2009
Externally published	Yes

Keywords

Ca2+ mobilisation
Ca2+ stores
Ca2+-induced Ca2+ release
Calcium signalling
Calcium transient
Cholecystokinin
Endothelin
Inositol 1,4,5-trisphosphate
Ion channel
Pancreatic β-cell

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10.1007/s00424-009-0682-y

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title = "The acid test: The discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels",

abstract = "In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.",

keywords = "Ca2+ mobilisation, Ca2+ stores, Ca2+-induced Ca2+ release, Calcium signalling, Calcium transient, Cholecystokinin, Endothelin, Inositol 1,4,5-trisphosphate, Ion channel, Pancreatic β-cell",

author = "Antony Galione and Evans, {A. Mark} and Jianjie Ma and John Parrington and Abdelilah Arredouani and Xiaotong Cheng and Zhu, {Michael X.}",

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doi = "10.1007/s00424-009-0682-y",

language = "English",

volume = "458",

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AU - Galione, Antony

AU - Evans, A. Mark

AU - Ma, Jianjie

AU - Parrington, John

AU - Arredouani, Abdelilah

AU - Cheng, Xiaotong

AU - Zhu, Michael X.

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AB - In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.

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KW - Calcium signalling

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The acid test: The discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca²⁺ release channels

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Keywords

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