The critical role of O2 provision in the dynamic adjustment of oxidative phosphorylation

Juan M. Murias; Matthew D. Spencer; Donald H. Paterson

doi:10.1249/JES.0000000000000005

The critical role of O₂ provision in the dynamic adjustment of oxidative phosphorylation

Juan M. Murias, Matthew D. Spencer, Donald H. Paterson^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

56 Citations (Scopus)

Abstract

It has been proposed that the adjustment of oxygen uptake (V̇O ₂) during the exercise on-transient is controlled intracellularly in young healthy individuals and that insufficient local O₂ delivery plays a rate-limiting role in aging and disease only. This review shows that adequate O₂ provision to the active tissues is critical in the dynamic adjustment of oxidative phosphorylation even in young healthy individuals.

Original language	English
Pages (from-to)	4-11
Number of pages	8
Journal	Exercise and Sport Sciences Reviews
Volume	42
Issue number	1
DOIs	https://doi.org/10.1249/JES.0000000000000005
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

O2 extraction
VO kinetics
blood flow
moderate-intensity exercise
near-infrared spectroscopy

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10.1249/JES.0000000000000005

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abstract = "It has been proposed that the adjustment of oxygen uptake ({\.V}O 2) during the exercise on-transient is controlled intracellularly in young healthy individuals and that insufficient local O2 delivery plays a rate-limiting role in aging and disease only. This review shows that adequate O2 provision to the active tissues is critical in the dynamic adjustment of oxidative phosphorylation even in young healthy individuals.",

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AB - It has been proposed that the adjustment of oxygen uptake (V̇O 2) during the exercise on-transient is controlled intracellularly in young healthy individuals and that insufficient local O2 delivery plays a rate-limiting role in aging and disease only. This review shows that adequate O2 provision to the active tissues is critical in the dynamic adjustment of oxidative phosphorylation even in young healthy individuals.

KW - O2 extraction

KW - VO kinetics

KW - blood flow

KW - moderate-intensity exercise

KW - near-infrared spectroscopy

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The critical role of O₂ provision in the dynamic adjustment of oxidative phosphorylation

Abstract

Keywords

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