The effect of local breast radiotherapy on circulating CD34 + cells

Nehad M. Alajez; Wei Wang; Debashis Biswas; Amy Teh; Robert Sutherland; Melania Pintilie; Mark Minden; Hans Messner; Anthony Fyles; Mary Gospodarowicz; Armand Keating; Fei Fei Liu

doi:10.1016/j.radonc.2011.01.003

The effect of local breast radiotherapy on circulating CD34 ⁺ cells

Nehad M. Alajez, Wei Wang, Debashis Biswas, Amy Teh, Robert Sutherland, Melania Pintilie, Mark Minden, Hans Messner, Anthony Fyles, Mary Gospodarowicz, Armand Keating, Fei Fei Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The number of circulating CD34 ⁺ (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.

Original language	English
Pages (from-to)	304-307
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	100
Issue number	2
DOIs	https://doi.org/10.1016/j.radonc.2011.01.003
Publication status	Published - Aug 2011
Externally published	Yes

Keywords

Breast cancer
Hematopoietic stem cells
Homing
Radiation therapy

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10.1016/j.radonc.2011.01.003

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title = "The effect of local breast radiotherapy on circulating CD34 + cells",

abstract = "The number of circulating CD34 + (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.",

keywords = "Breast cancer, Hematopoietic stem cells, Homing, Radiation therapy",

author = "Alajez, {Nehad M.} and Wei Wang and Debashis Biswas and Amy Teh and Robert Sutherland and Melania Pintilie and Mark Minden and Hans Messner and Anthony Fyles and Mary Gospodarowicz and Armand Keating and Liu, {Fei Fei}",

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language = "English",

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T1 - The effect of local breast radiotherapy on circulating CD34 + cells

AU - Alajez, Nehad M.

AU - Wang, Wei

AU - Biswas, Debashis

AU - Teh, Amy

AU - Sutherland, Robert

AU - Pintilie, Melania

AU - Minden, Mark

AU - Messner, Hans

AU - Fyles, Anthony

AU - Gospodarowicz, Mary

AU - Keating, Armand

AU - Liu, Fei Fei

PY - 2011/8

Y1 - 2011/8

N2 - The number of circulating CD34 + (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.

AB - The number of circulating CD34 + (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.

KW - Breast cancer

KW - Hematopoietic stem cells

KW - Homing

KW - Radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=80052299807&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2011.01.003

DO - 10.1016/j.radonc.2011.01.003

M3 - Article

C2 - 21316784

AN - SCOPUS:80052299807

SN - 0167-8140

VL - 100

SP - 304

EP - 307

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 2

ER -

The effect of local breast radiotherapy on circulating CD34 ⁺ cells

Abstract

Keywords

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