TY - JOUR
T1 - The Prevalence of Phenylketonuria in Arab Countries, Turkey, and Iran
T2 - A Systematic Review
AU - El-Metwally, Ashraf
AU - Yousef Al-Ahaidib, Lujane
AU - Ayman Sunqurah, Alaa
AU - Al-Surimi, Khaled
AU - Househ, Mowafa
AU - Alshehri, Ali
AU - Da'Ar, Omar B.
AU - Abdul Razzak, Hira
AU - Alodaib, Ali Nasser
N1 - Publisher Copyright:
© 2018 Ashraf El-Metwally et al.
PY - 2018
Y1 - 2018
N2 - Background/Objectives. This paper seeks to identify the prevalence of Phenylketonuria (PKU) in Arab countries, Turkey, and Iran. The study reviewed the existence of comprehensive national newborn screening programs and reported consanguinity rates. Methods. A computer based literature search was conducted using relevant keywords to retrieve studies conducted on PKU. A total of 34 articles were included. Prevalence was categorized based on the type of screening method used for PKU diagnoses. Results. The prevalence of classical PKU diagnosed through a comprehensive national newborn screening program ranged from 0.005% to 0.0167%. The highest prevalence was reported in Turkey at 0.0167%, whereas the lowest prevalence was reported in the UAE, 0.005%. Conclusion. The findings of this review emphasize the need for the establishment of more efficient reporting systems in these countries that would help measure Disability-Adjusted Life Year (DALY) in order to estimate the overall societal burden of PKU.
AB - Background/Objectives. This paper seeks to identify the prevalence of Phenylketonuria (PKU) in Arab countries, Turkey, and Iran. The study reviewed the existence of comprehensive national newborn screening programs and reported consanguinity rates. Methods. A computer based literature search was conducted using relevant keywords to retrieve studies conducted on PKU. A total of 34 articles were included. Prevalence was categorized based on the type of screening method used for PKU diagnoses. Results. The prevalence of classical PKU diagnosed through a comprehensive national newborn screening program ranged from 0.005% to 0.0167%. The highest prevalence was reported in Turkey at 0.0167%, whereas the lowest prevalence was reported in the UAE, 0.005%. Conclusion. The findings of this review emphasize the need for the establishment of more efficient reporting systems in these countries that would help measure Disability-Adjusted Life Year (DALY) in order to estimate the overall societal burden of PKU.
UR - http://www.scopus.com/inward/record.url?scp=85048697978&partnerID=8YFLogxK
U2 - 10.1155/2018/7697210
DO - 10.1155/2018/7697210
M3 - Review article
C2 - 29850564
AN - SCOPUS:85048697978
SN - 2314-6133
VL - 2018
JO - BioMed Research International
JF - BioMed Research International
M1 - 7697210
ER -