TY - JOUR
T1 - The relationship between oxygen uptake kinetics and neuromuscular fatigue in high-intensity cycling exercise
AU - Temesi, John
AU - Mattioni Maturana, Felipe
AU - Peyrard, Arthur
AU - Piucco, Tatiane
AU - Murias, Juan M.
AU - Millet, Guillaume Y.
N1 - Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Purpose: In theory, a slow oxygen uptake (V˙ O2) kinetics leads to a greater accumulation of anaerobic by-products, which can, in turn, induce more neuromuscular fatigue. However, the existence of this relationship has never been tested. Methods: After two sessions to measure peak V˙ O2, peak power output (POpeak), and V˙ O2 kinetics responses in the unfatigued state (τ V˙ O2 MOD), 10 healthy young adults performed a 6-min cycling bout at 80% POpeak (INT6-min). V˙ O2 kinetics responses were also measured during INT6-min. Neuromuscular fatigue was measured isometrically pre- and post-INT6-min (immediately post- and 15-s post-INT6-min) with an innovative cycle ergometer. Results: Maximal voluntary contraction (MVC) force, high-frequency doublet amplitude, and the ratio of low- to high-frequency doublet amplitudes decreased by 34 ± 7, 43 ± 11, and 31 ± 13%, respectively (all P < 0.01). A significant Spearman’s rank correlation was observed between the change in low-frequency doublet force (ΔDb10) immediately after INT6-min and both τ V˙ O2 MOD and τ V˙ O2 INT6-min (ρ = −0.68 and ρ = −0.67, both P < 0.05). When considering the largest responses from the two neuromuscular evaluations post-INT6-min, significant correlations were also found between τ V˙ O2 MOD and ΔDb10 (ρ = −0.74; P < 0.05) and between τV˙ O2 INT6-min and both ΔDb10 and low-frequency fatigue (ρ = −0.70 and ρ = −0.66; both P < 0.05). Conclusion: The present results suggest that subjects with slow V˙ O2 kinetics experience more peripheral fatigue, in particular more excitation–contraction coupling failure, likely due to a greater accumulation of protons and/or inorganic phosphates.
AB - Purpose: In theory, a slow oxygen uptake (V˙ O2) kinetics leads to a greater accumulation of anaerobic by-products, which can, in turn, induce more neuromuscular fatigue. However, the existence of this relationship has never been tested. Methods: After two sessions to measure peak V˙ O2, peak power output (POpeak), and V˙ O2 kinetics responses in the unfatigued state (τ V˙ O2 MOD), 10 healthy young adults performed a 6-min cycling bout at 80% POpeak (INT6-min). V˙ O2 kinetics responses were also measured during INT6-min. Neuromuscular fatigue was measured isometrically pre- and post-INT6-min (immediately post- and 15-s post-INT6-min) with an innovative cycle ergometer. Results: Maximal voluntary contraction (MVC) force, high-frequency doublet amplitude, and the ratio of low- to high-frequency doublet amplitudes decreased by 34 ± 7, 43 ± 11, and 31 ± 13%, respectively (all P < 0.01). A significant Spearman’s rank correlation was observed between the change in low-frequency doublet force (ΔDb10) immediately after INT6-min and both τ V˙ O2 MOD and τ V˙ O2 INT6-min (ρ = −0.68 and ρ = −0.67, both P < 0.05). When considering the largest responses from the two neuromuscular evaluations post-INT6-min, significant correlations were also found between τ V˙ O2 MOD and ΔDb10 (ρ = −0.74; P < 0.05) and between τV˙ O2 INT6-min and both ΔDb10 and low-frequency fatigue (ρ = −0.70 and ρ = −0.66; both P < 0.05). Conclusion: The present results suggest that subjects with slow V˙ O2 kinetics experience more peripheral fatigue, in particular more excitation–contraction coupling failure, likely due to a greater accumulation of protons and/or inorganic phosphates.
KW - Excitation–contraction coupling failure
KW - Intense cycling exercise
KW - Muscle fatigue
KW - Oxygen uptake kinetics
UR - http://www.scopus.com/inward/record.url?scp=85027950376&partnerID=8YFLogxK
U2 - 10.1007/s00421-017-3585-1
DO - 10.1007/s00421-017-3585-1
M3 - Article
C2 - 28357580
AN - SCOPUS:85027950376
SN - 1439-6319
VL - 117
SP - 969
EP - 978
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 5
ER -