The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure

Julie Douville; Jocelyn David; Karine M. Lemieux; Luc Gaudreau; Dindial Ramotar

doi:10.1534/genetics.105.046110

The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure

Julie Douville, Jocelyn David, Karine M. Lemieux, Luc Gaudreau, Dindial Ramotar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.

Original language	English
Pages (from-to)	1369-1372
Number of pages	4
Journal	Genetics
Volume	172
Issue number	2
DOIs	https://doi.org/10.1534/genetics.105.046110
Publication status	Published - Feb 2006
Externally published	Yes

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title = "The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure",

abstract = "We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.",

author = "Julie Douville and Jocelyn David and Lemieux, {Karine M.} and Luc Gaudreau and Dindial Ramotar",

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AU - Ramotar, Dindial

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AB - We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.

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The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure

Abstract

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