The TIF1α-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression

Benjamin Herquel, Khalid Ouararhni, Irwin Davidson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

TRIM24 (TIF1α), TRIM28 (TIF1β) and TRIM33 (TIF1γ) are related cofactors defining a subgroup of the tripartite motif (TRIM) superfamily comprising an N-terminal RING finger E3 ligase and a C-terminal PHD-Bromodomain chromatin interacting module. Increasing evidence highlights the important roles of these proteins as modulators of multiple signaling pathways during normal development and as tumor suppressors. The finding that they interact to form a multiprotein complex suggests new mechanisms to integrate multiple signaling pathways for tumor suppression.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalTranscription
Volume2
Issue number5
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Hematopoeisis
  • Retinoic acid
  • SMAD4
  • TGFβ
  • Transcriptional repression

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