Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

Asif Ali; Markus R. Wenk; Martin J. Lear

doi:10.1016/j.tetlet.2009.07.109

Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

Asif Ali, Markus R. Wenk, Martin J. Lear^*

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its d-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2).

Original language	English
Pages (from-to)	5664-5666
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	40
DOIs	https://doi.org/10.1016/j.tetlet.2009.07.109
Publication status	Published - 7 Oct 2009
Externally published	Yes

Access to Document

10.1016/j.tetlet.2009.07.109

Cite this

@article{3dacd5f4122f4e21bf4afa8b3b62b6e0,

title = "Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis",

abstract = "Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its d-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2).",

author = "Asif Ali and Wenk, {Markus R.} and Lear, {Martin J.}",

year = "2009",

month = oct,

day = "7",

doi = "10.1016/j.tetlet.2009.07.109",

language = "English",

volume = "50",

pages = "5664--5666",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "40",

}

TY - JOUR

T1 - Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

AU - Ali, Asif

AU - Wenk, Markus R.

AU - Lear, Martin J.

PY - 2009/10/7

Y1 - 2009/10/7

N2 - Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its d-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2).

AB - Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its d-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2).

UR - http://www.scopus.com/inward/record.url?scp=68949175683&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2009.07.109

DO - 10.1016/j.tetlet.2009.07.109

M3 - Article

AN - SCOPUS:68949175683

SN - 0040-4039

VL - 50

SP - 5664

EP - 5666

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this