Vascular responsiveness determined by near-infrared spectroscopy measures of oxygen saturation

Kaitlin M. McLay; Federico Y. Fontana; Josh P. Nederveen; Federico F. Guida; Donald H. Paterson; Silvia Pogliaghi; Juan M. Murias

doi:10.1113/EP085406

Vascular responsiveness determined by near-infrared spectroscopy measures of oxygen saturation

Kaitlin M. McLay, Federico Y. Fontana, Josh P. Nederveen, Federico F. Guida, Donald H. Paterson, Silvia Pogliaghi, Juan M. Murias^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

New Findings: What is the central question of this study? Can the near-infrared spectroscopy (NIRS)-derived reperfusion rate (slope 2) of tissue oxygen saturation (StO₂) be correlated with flow-mediated dilation (FMD), the commonly used method to assess vascular endothelial function? What is the main finding and its importance? The present data were able to establish a correlation between the reperfusion rate of StO₂ and percentage FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO₂ can be used as a measure of vascular endothelial function. Vascular impairments at the macro- and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow-mediated dilation (FMD) is currently the most widely used method for non-invasive assessment of vascular endothelial function. Recently, near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO₂) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of StO₂ and FMD. Ultrasound-derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end-diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The StO₂ was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and StO₂. The %FMD was significantly correlated with the reperfusion slope of StO₂ after cuff release (slope 2 StO₂; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 StO₂ and %FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO₂ can be used as a measure of vascular endothelial function.

Original language	English
Pages (from-to)	34-40
Number of pages	7
Journal	Experimental Physiology
Volume	101
Issue number	1
DOIs	https://doi.org/10.1113/EP085406
Publication status	Published - 2016
Externally published	Yes

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title = "Vascular responsiveness determined by near-infrared spectroscopy measures of oxygen saturation",

abstract = "New Findings: What is the central question of this study? Can the near-infrared spectroscopy (NIRS)-derived reperfusion rate (slope 2) of tissue oxygen saturation (StO2) be correlated with flow-mediated dilation (FMD), the commonly used method to assess vascular endothelial function? What is the main finding and its importance? The present data were able to establish a correlation between the reperfusion rate of StO2 and percentage FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function. Vascular impairments at the macro- and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow-mediated dilation (FMD) is currently the most widely used method for non-invasive assessment of vascular endothelial function. Recently, near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of StO2 and FMD. Ultrasound-derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end-diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The StO2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and StO2. The %FMD was significantly correlated with the reperfusion slope of StO2 after cuff release (slope 2 StO2; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 StO2 and %FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function.",

author = "McLay, {Kaitlin M.} and Fontana, {Federico Y.} and Nederveen, {Josh P.} and Guida, {Federico F.} and Paterson, {Donald H.} and Silvia Pogliaghi and Murias, {Juan M.}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors. Experimental Physiology {\textcopyright} 2015 The Physiological Society",

year = "2016",

doi = "10.1113/EP085406",

language = "English",

volume = "101",

pages = "34--40",

journal = "Experimental Physiology",

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T1 - Vascular responsiveness determined by near-infrared spectroscopy measures of oxygen saturation

AU - McLay, Kaitlin M.

AU - Fontana, Federico Y.

AU - Nederveen, Josh P.

AU - Guida, Federico F.

AU - Paterson, Donald H.

AU - Pogliaghi, Silvia

AU - Murias, Juan M.

PY - 2016

Y1 - 2016

N2 - New Findings: What is the central question of this study? Can the near-infrared spectroscopy (NIRS)-derived reperfusion rate (slope 2) of tissue oxygen saturation (StO2) be correlated with flow-mediated dilation (FMD), the commonly used method to assess vascular endothelial function? What is the main finding and its importance? The present data were able to establish a correlation between the reperfusion rate of StO2 and percentage FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function. Vascular impairments at the macro- and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow-mediated dilation (FMD) is currently the most widely used method for non-invasive assessment of vascular endothelial function. Recently, near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of StO2 and FMD. Ultrasound-derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end-diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The StO2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and StO2. The %FMD was significantly correlated with the reperfusion slope of StO2 after cuff release (slope 2 StO2; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 StO2 and %FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function.

AB - New Findings: What is the central question of this study? Can the near-infrared spectroscopy (NIRS)-derived reperfusion rate (slope 2) of tissue oxygen saturation (StO2) be correlated with flow-mediated dilation (FMD), the commonly used method to assess vascular endothelial function? What is the main finding and its importance? The present data were able to establish a correlation between the reperfusion rate of StO2 and percentage FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function. Vascular impairments at the macro- and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow-mediated dilation (FMD) is currently the most widely used method for non-invasive assessment of vascular endothelial function. Recently, near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of StO2 and FMD. Ultrasound-derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end-diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The StO2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and StO2. The %FMD was significantly correlated with the reperfusion slope of StO2 after cuff release (slope 2 StO2; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 StO2 and %FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function.

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JO - Experimental Physiology

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Vascular responsiveness determined by near-infrared spectroscopy measures of oxygen saturation

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