VERLANGSAMTE LIDOCAIN-ELIMINATION UND DOSISANPASSUNG BEI PATIENTEN MIT HERZINSUFFIZIENZ

Translated title of the contribution: Slowing of lidocaine elimination and dose adjustment in patients with cardiac failure

F. Follath, R. Ritz, S. Vozeh, M. Wenk

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

In 21 patients with acute coronary artery disease the influence of cardiac failure on the elimination of lidocaine (L) was evaluated by repeated serum level measurements during and after a therapeutic L-infusion. Lidocaine clearance (C1) was <8 ml/min/kg in 9 of 13 cases with congestive heart failure (CHF), while in 7 out of 8 patients without CHF C1-values were 8-12 ml/min/kg. Due to wide interindividual variability in the CHF group, however, mean values were not significantly different: 7.3±2.9 vs. 9.52±1.54 ml/min/kg (p>0.05). In 3 patients receiving a simultaneous nitroglycerine infusion C1 was >10 ml/min/kg despite clinical signs of CHF. The t 1/2 of L was significantly prolonged in patients with CHF: 4.29±2.14 vs. 2.43±0.58 h (p<0.05). It was not possible to determine individual L-dose requirements by bedside clinical examination alone. Serum level monitoring is therefore recommended in order to optimize L-therapy in patients with life-threatening arrhythmias, severe congestive heart failure and hypotension.

Translated title of the contributionSlowing of lidocaine elimination and dose adjustment in patients with cardiac failure
Original languageGerman
Pages (from-to)789-791
Number of pages3
JournalSchweizerische Medizinische Wochenschrift
Volume112
Issue number22
Publication statusPublished - 1982
Externally publishedYes

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